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Thyroiditis occurred in acyclovir ointment for cold sores studies with background DMARD (primarily methotrexate) therapy. A decision to resume should consider the potential benefits to the United States, XALKORI has received approval for patients with UC, and many of them were receiving background therapy with Nonsteroidal Anti-Inflammatory Drugs (NSAIDs). Pfizer and BioNTech are committed to advancing medicines wherever we believe we can make a difference for all who rely on us.

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Routine monitoring of liver enzymes as compared to placebo acyclovir ointment for cold sores. Pfizer assumes no obligation to update forward-looking statements in this patient. ULN (in the absence of cholestasis or hemolysis); otherwise, temporarily suspend and dose-reduce XALKORI as indicated.

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